Experimental Hair Loss Options

[hello]

Yeah but now pehaps his body is enormously screwed

FOR SURE :

Current regimen:0.5mg dutasteride - 1x/day200mg spironolactone - 1x100mg/morning, 1x100mg/night6mg estradiol valerate (oral/sublingual) - 1x2mg/morning, 1x2mg/midday, 1x2mg/night5mg medroxyprogesterone - 1x/day5% minoxidil liquid (2 to 3 mL from my crown to just behind my hairline) - 1x/day15% minoxidil liquid (1 mL on the hairline/temples/temple points) - 1x/day

.

but, about this:

Dermarolling with a 1.5mm roller 1x/week (no topicals on this day & I only did my temples/hairline)Lithium Chloride immediately after dermarolling

I think this is very good, and we should do part of it too. After we halted the shedding with our protocols, We could speed up a lot the process of regrow with induced woundings with dermaroller or Dermapen, and then Copper peptide GHK-Cu or Valproic acid or Lithium Chloride.



Copper peptide GHK-Cu. :

Analysis of the folliculograms was also performed in the fuzzy rat and both minoxidil and PC1031 (Peptide;ghkvfv-copper, 2: 1 complex) induced progression of the cycle and elongation of follicular size after 2 to 4 months of treatment compared to the patterns of vehicle groups [l I].

The patterns of folliculograms in non-bald pre-pubertal macaques showed large follicles in all cyclic phases and the majority of the follicles belonged to the anagen hase with both the mid and late phases. This non-bald pattern of Polliculogram was maintained by either topical application of antiandrogen (4MA) or minoxidil (5%) in the frontal scalp during the peripubertal age (about 3 to 5 years) [lo,1 l]. In the same age group the maca ues treated with vehicle showed a conversion of the folliculogram srom the non-bald to the bald pattern.

Unlike other rodents, the hair follicles in fuzzy rats exhibited non-synchronized cyclic growth after the second postnatal cycle. At the age of two and a half months, the ratio of telogen and anagen follicles was about SO/SOand all follicles were small; the average length was 0.3 mm in telogen follicles and 0.75 mm in anagen follicles. Both minoxidil and PC1031 (5% res ectively) induced an 80% increase in the population of anagen fol Ficles and an enlarge- ment to almost double in size. .

Chemical Agents and Peptides Affect Hair Growth
GHK Peptide as a Natural Modulator of Multiple Cellular Pathways in Skin Regeneration

VPA:

Targeting of CXXC5 by a Competing Peptide Stimulates Hair Re-growth and Wound- Induced Hair Neogenesis -> http://doi.org.https.sci-hub.hk/10.1016/j.jid.2017.04.038
Topical valproic acid increases the hair count in male patients with androgenetic alopecia: a randomized, comparative, clinical feasibility study u... - PubMed - NCBI
Valproic Acid Induces Hair Regeneration in Murine Model and Activates Alkaline Phosphatase Activity in Human Dermal Papilla Cells
Valproic Acid Induces Cutaneous Wound Healing In Vivo and Enhances Keratinocyte Motility

quote from Topical valproic acid increases the hair count in male patients with androgenetic alopecia: A randomized, comparative, clinical feasibility study using phototrichogram analysis

Serum VPA concentration

The serum VPA concentration was measured in 20 subjects in the VPA group and 19 subjects in the placebo group. The serum VPA level was detectable in only seven subjects in the VPA group (range, 0.4–2.3 lg/mL), whereas it was too low (<0.4 lg/mL) to be detected in the other 13 subjects in the VPA group and all of the subjects in the placebo group.

and this:

Safety assessment

During the 24-week study period, 11 of the 40 subjects experi- enced adverse events, including local skin problems and insomnia (Table 2), most of which were mild and self-limited. However, a subject in the VPA group developed ventricular tachycardia, a serious adverse event that originated from the left anterior fascicle, and dropped out of the study. The prevalence rates of the adverse events were not significantly different between both groups (P = 0.72).

@gbolduev What is your view on VPA in relation with balance and possible intervention in mineral balance or hormonal balance?

 

[hairloser]

FOR SURE :

.

but, about this:


I think this is very good, and we schould do it too. After we halted the shedding with our protocols, We could speed up a lot the process of regrow with induced woundings with dermaroller or Dermapen, and then Copper peptide GHK-Cu or Lithium Chloride , or Valproic acid.



Copper peptide GHK-Cu
Chemical agents and peptides affect hair growth - ScienceDirect

GHK Peptide as a Natural Modulator of Multiple Cellular Pathways in Skin Regeneration

VPA http://doi.org.https.sci-hub.hk/10.1016/j.jid.2017.04.038

Topical valproic acid increases the hair count in male patients with androgenetic alopecia: a randomized, comparative, clinical feasibility study u... - PubMed - NCBI
Valproic Acid Induces Cutaneous Wound Healing In Vivo and Enhances Keratinocyte Motility
Valproic Acid Induces Hair Regeneration in Murine Model and Activates Alkaline Phosphatase Activity in Human Dermal Papilla Cells

Actually what I don't understand is why dermarolling wouldn't cause scarring?

 

[mattyb]

One thing I am specifically interested in, but haven't been able to find any literature, is how hairs shift from vellus to terminal on the head. I have full coverage on my head with vellus hairs, but I can't get them to turn over into terminal hairs. When I see my head in a certain types of lighting it looks like I actually have hair again. I don't even need knew follicles or anything, I just need hairs to go terminal.

Has anyone found any lit reviews or papers on how hairs become terminal?

 

[hello]

One thing I am specifically interested in, but haven't been able to find any literature, is how hairs shift from vellus to terminal on the head. I have full coverage on my head with vellus hairs, but I can't get them to turn over into terminal hairs. When I see my head in a certain types of lighting it looks like I actually have hair again. I don't even need knew follicles or anything, I just need hairs to go terminal.

Has anyone found any lit reviews or papers on how hairs become terminal?

HMMM, look what I have found.

Hair regrowth in male and female pattern hair loss does not involve the conversion of vellus hair to terminal hair

Conclusion
We would propose there is a population of growth restricted (dor- mant/kenogen) non-vellus hair follicles, which are re-activated by effective medical treatments as an explanation for the increased hair growth observed in FPHL and MPHL. Our findings have a fundamental impact on the pathophysiology of hair changes occurring in patterned hair loss.

http://doi.org.https.sci-hub.hk/10.1111/exd.12945

Of course they say this based on traditional treatments , fin+minox .
We know that this is not the normal grow of the human hair. So we don't know for sure if this is true or not 100% .

 

[Helen]

One thing I am specifically interested in, but haven't been able to find any literature, is how hairs shift from vellus to terminal on the head. I have full coverage on my head with vellus hairs, but I can't get them to turn over into terminal hairs. When I see my head in a certain types of lighting it looks like I actually have hair again. I don't even need knew follicles or anything, I just need hairs to go terminal.

Has anyone found any lit reviews or papers on how hairs become terminal?

Keratin problem.

 

[Blue88]

Hi @gbolduev

An update from me.

If you remember, my hair test from early October had extremely high calcium and low boron, pointing to a parathyroid issue. At the time, I was taken a lot of supplements. All other minerals looked fairly good. The report suggested I was a slow oxidiser, but you seemed to think that results (other than calcium) pointed to me being a fast oxidiser.

I stopped all supplements at the end of November and had blood tests for prolactin, calcium and parathyroid on 5th January, as you mentioned. My results are as follow:

Calcium - 2.49 mmol/L (range: 2.20 - 2.60)
Prolactin - 135 mIU/L (range: 86 - 324)
Intact-(whole molecule) PTH - 5.0 pmol/L (range: 1.6 - 6.9)

Over the past week, my shedding seems to have slowed. My diet now mainly consists of seafood (shellfish, sardines), eggs, spinach, sweet potato, salt and almond butter.

I'm going to do another hair test (includes aminos), but how do the above results look to you? Any recommendations?

Perhaps coming off the supplements has helped.

@gbolduev - any comments on this, please?

 

[JDreamer]

Anyone know if the glucuronidation pathway is involved with hair loss at any level?

 

[JDreamer]

By the way, the weather is really nice here right now. Nice enough that I laid out at the pool yesterday. I haven't been outside like that in months, especially since I'm always trapped inside of an office.

I was quickly reminded how much sunlight affects hair quality.

 

[Blue88]

@gbolduev - any comments on this, please?

Hi @gbolduev , grateful for any advice on my case.

 

[Noodle]

@gbolduev Do you think it is possible to pin down a optimal hair test for hair (growth)? What things could point to hairloss? Like low iron, high copper? Or high calcium ?

Those hair test practitioners often don’t look too good hair wise.

 

[JDreamer]

So where are we at? Anyone having legitimate success that they can demonstrate?

 

[MNK99]

Any males use Bimatroprost (Latisse) to regrow eyelashes and or eyebrows? Lol.
I'm just wondering. My eyebrows were great, now I swear they're thinner since I began rx stimulants 4 yrs ago or so. Also overwaxed the years prior to that. I haven't taken the rx stimulants in over a year, but maybe finasteride or lamotrigine thinned them too. Also eyelashes are thinner than in teens, early 20's.

@TubZy you tried this for scalp hair? How many bottles are necessary? What are the major downsides?

Whenever I restart stimulants, I can rub my scalp hair and it falls out a bit, also with my eyebrows. Some thyroid issue perhaps. I'm sure I've checked at least twice out of paranoia, but never came back as anything clinically substantial. I actually used some Spiro cream on my eyebrows back then, just in case.
-I think it's cortisol,
-peripheral nervous system side effects,
-vasoconstriction,
-or telogen effluvium.
-Maybe androgenic activity?

-WAY worse on Adderall vs. Dexedrine. But, that first shock was major hair loss -- If I started with thin hair, I think after Adderall(2 nights) and Lamotrigine(89d), it'd be over.
-Also my hair was wavy and the hairs that fell out in strange freyed, jagged shafts. Like the hair looked like I was electrocuted almost.
-And my hair became increasingly straight.
-If it was telogen effluvium, it would have been shock/stress finding out about diagnosis/ and remembering past with other meds... but usually "TE" is from a major serious life change... whatever that means.
-Thinner with lamotrigine. I guess they were always somewhat fine, as they are with my ethnicity usually -- but it was very "thick" in terms of "density".
-Wavy and needing to be thinned out at salons --> thin, lifeless at times, and more straight. Very odd.
-Every ADHD stimulant (tried the big 4) and Anticonvulsants caused shedding. And on net as a group, increased the number of "parts" in my hair.

 

[JDreamer]

Perhaps this is the wrong place to put all of this, but somehow my morning erections are back.

For the past few weeks, I've been dosing 2grams of Taurine and 1gram of Ester-C before my workout and then another 1gram of Ester-C before I go to bed. Should note that I chew the pills to try to get it transported sublingually instead of relying on my shitty digestion. Nearly every single morning I've been hard as a rock when waking up. Dreams are also less nightmarish and more memorable.

Also wanted to note a couple things about the hair. I went old school and brought back the head massaging in the morning and hanging upside for a couple minutes. There is no doubt in my mind my hair feels better/fuller. I can always tell because I require far less hair fibers on my crown (in the front is still a whole other story). That's basically the only area up near the top that I can fully pinch together. Going to continue to try to stretch the scalp up there, but I would like to find something that could help it along - kind similar to how you tenderize meat (go back to dermaroller?).

 

[Greg313]

Pumpkin seed oil worked really well for my hair when I took it for about a month. Hair got much thicker and fuller. It’s a weak 5a reductase inhibitor but I think it was the minerals in it that gave me such good results. I stopped taking it because of pufa.

 

[HerrFisch]

@gbolduev
Have you ever had problems with balding temples, and do you think its harder to see regrowth there?

 

[heygate]

https://satthwa.quora.com/How-i-mad...-how-you-can-make-it-too-giving-out-my-secret

good hair oil recipe for anyone thats interested, been using it myself, Not a miracle, but helps along with a good head massage every night.

 

[snowball]

Here is a new potential hair loss cure:
Baldness cure could be found in an osteoporosis drug, study finds

 

[TubZy]

topical malic acid or topical dead sea salt (suspended in water or olive oil)

 

[heygate]

@TubZy out of interest what does malic acid do topically for hair growth? And have you tried it? Also have you had any results from a salt scrub?

 

[TubZy]

@TubZy out of interest what does malic acid do topically for hair growth? And have you tried it? Also have you had any results from a salt scrub?

Can decalify scalp
Sulphoraphane as an inducer of 3 alpha hsd.( DHT to metabolites conversion) HAIRLOSS, PFS, COPD, CANCER PSSD

Sea salt scrubs work, but I found it has to be the finely refined sea salt, much easier to scrub with it, I use the Morton one. For me, kills any scalp itch and makes my hair look nice, I have been doing it for a while once a day in the shower. I looked more into it and there are some methods of dead sea salt solutions which may work better due to much higher mineral concentration.