Hi, I understand you all are so exciting about potassium. but I would not be so fast. since we have several cases here
I think we need to consider several possibilities.
1) progesterone is high since there is too sensitive cortisol and cortisol is wasting potassium.
In this case we need to do something with the cortisol and let the body retain potassium
2) progesterone is high , since we are missing NADPH and it cant be broken down to cortisol or neurosteroids. in this case there is very little production of cortisol and cortisol in urine is very low. and the body is trying to retain it as much as possible, and thus upregulated its receptors which also upregulated AR receptors.
In this case the body tries to conserve all hormones that need NADPH to be made. which is cortisol, DHT testosterone estrogens. ( those all should be low in the urine) the body cant make them in proper amounts. And it stops pissing them out totally. And it upregulates the AR receptors, since it knows that it cant make those in proper amounts.
May be this is why people feel better on licorice which stops cortisol break down into cortisone.( although logically in this case it would be just a stilt)
Progesterone gets converted to cortisol via NADPH. NADPH is made with B1 NAD and phosphorus. I assume people who feel like shit on b1 probably are low on phosphorus. And there is a thing called phosphorus diabetes. Which is very close to what is experienced in PFS.
In this case potassium is being retained uncontrollable. And thus it puts pressure on very WEAK cortisol. and thus AR receptor is freaking out.
In this case, zinc will be pissed out int the urine along with vitamin B2.
In this case I would try b1 to increase NADPH . along with phosphorus This should lower progesterone and increase cortisol, which will kill potassium in the cell. And the body will start asking for zinc and b2 to make new progesterone, to retain potassium.
Just imagine if progesterone cant be broken down. Then it just sits there and the body downregulates its production ( progesterone is produced via zinc and b2. b6)
So the body downregulates zinc and pisses it out not to create more progesterone and people experience zinc deficiency but cant take zinc
If we kill progestreone with NADPH by converting it to cortisol and neurosteroids. All of a sudden progesterone will be very low. and potassium will crash in the cell. The body will ask for more zinc and b2 to make NEW progesterone. to retain potassium and this will make zinc bioavailable
SO the meaning of this case, is that the body usually has zinc and b2 active making progesterone. But in case when progesterone cant be broken down further into cortisol or neurosteroids. The body totally downregulate zinc and b2. and it cant make much cortisol, thus it retains it, meaning does not piss it out. As cortisol gets very weak. androgen also dont work. since they are scared to build shit from protein, if there is no cortisol to actually get to protein in case of stress.
Bottom line we need to try these 2 cases.