RU / "Mifepristone Challenge" Log

[joekool]

@Boris You see this guy reacts to RU completely differently. He does not feel recovered on RU.

Since @Boris you had high cortisol and 4 highs, cortisol retains sodium, which stops 5AR

Slow oxidizers usually have low sodium , very low sodium levels. and thus 5AR and DHT usually high. So @bruschi11 and @jinstewart don't feel recovered and actually feel worse erection wise while on RU. Since RU by blocking cortisol , probably lowers their sodium even further. and the body has to convert dopamine into noradrenaline to activate the adregenic receptors more. thus their prolactin goes even higher

In your case @Boris , RU blocks cortisol, sodium retention falls. and this actually causes more 5AR.


hopefully something will happen on the snapback

Ohhh ok. Cuz here you said it blocks cortisol so I thought you meant it blocks cortisol

 

[RebelWithACause]

Isn't it because RU sits on the receptor so cortisol cannot bind and thus stays high in the blood.

 

[jinstewart]

RU486 is a cortisol receptor antagonist, so blocks cortisol, this causes - raises cortisol like crazy. this is why it is used in addisons to stimulate adrenal glands.

You know what I do think I remembered a little sort of 'ache' from what I thought was kidneys on occasion on the cycle. Could that have been adrenals?

 

[Helen]

Ohhh ok. Cuz here you said it blocks cortisol so I thought you meant it blocks cortisol

it does block cortisol literally, no cortisol action while on ru.

but when you come off, you can experience more cortisol.

 

[Helen]

You know what I do think I remembered a little sort of 'ache' from what I thought was kidneys on occasion on the cycle. Could that have been adrenals?

yeah , that was your adrenals pumping like there is no tomorrow.))

 

[joekool]

Isn't it because RU sits on the receptor so cortisol cannot bind and thus stays high in the blood.

This is making sense yes. I fear now the flood of cortisol could’ve been bad news for @jinstewart so very useful info overall here.

 

[TubZy]

Omg that’s amazing info! So test is super high and cortisol is crazy off the charts high. Even though some have said Mifepristone blocks cortisol, seems like opposite.

No, RU blocks it so it cant bind to the GR. If it can bind to GR it increases in serum. Interesting with the test increase, but if it blocks AR maybe that is why it increased.

Also prog rose dramatically so I wonder if this was just from blcoking the PR or agonist versus antagonism since it can do both? What do you think of his prog numbers? @Helen

And it looks like prolactin is normal (still within range) so taking caber or anything else for prolactin would to have little no effect if that is what you are trying to counteract anything.

Estradiol and cortisol through the roof as expected. So it looks like RU blocks GR, PR, ER and AR (will prob know more once DHT numbers come in)

 

[TubZy]

Yes, not sure on that. I also wondered if the RU rash is some sort of stress hives from the elevated cortisol, but idk myself.

@Helen these were taken during the cycle, morning of day 4 of 5. I thought the same, it blocks the receptor so cortisol goes mental-high to compensate then settles.

It's the opposite since cortisol isnt working, no? You probably got a rash because cortisol is anti inflammatory but since GR is bocked cortisol can't work. You got the rash while on right or after?

 

[joekool]

I see now, what happened. All makes sense and thanks for clearing it up. Very interesting indeed!

 

[Helen]

@Boris I saw these tests from another user after RU. it was the same.

RU blocks everything. ER, PR, AR, GR.

 

[bruschi11]

Is that how fasting works @Helen ? Similar to RU.

Because people say cortisol goes high during fast but you say it blocks cortisol. And I feel cortisol being blocked similar to RU on a fast.

And then it comes back stronger and lower because there are more receptors competing for it correct?

 

[jinstewart]

It's the opposite since cortisol isnt working, no? You probably got a rash because cortisol is anti inflammatory but since GR is bocked cortisol can't work. You got the rash while on right or after?

I noticed the rash on Monday, having stopped the RU the previous Wednesday. Call it 5 days post cessation.

 

[jinstewart]

This is making sense yes. I fear now the flood of cortisol could’ve been bad news for @jinstewart so very useful info overall here.

I did wonder about this, but @bruschi11 prepared me for a period of feeling like shit, which I might well still be in for! I'll see how it all pans out. I've made strides though, that's for sure. Kinda have this odd feeling of waiting for a 'second puberty' to hit at some point!

@Helen (and everybody really) I definitely think I'd like to do another run, 1g/day for 5 days. I'll leave it a couple of months though. Any thoughts on doing that?

Cheers everyone.

 

[Helen]

I did wonder about this, but @bruschi11 prepared me for a period of feeling like shit, which I might well still be in for! I'll see how it all pans out. I've made strides though, that's for sure. Kinda have this odd feeling of waiting for a 'second puberty' to hit at some point!

@Helen (and everybody really) I definitely think I'd like to do another run, 1g/day for 5 days. I'll leave it a couple of months though. Any thoughts on doing that?

Cheers everyone.

let the hormones settle and see where you are.

 

[TubZy]

The flood is technically what you want since you want your receptors to adjust post RU. It can be good or bad depending on the case which we still don't know yet, maybe RU could work for all cases, still too early to tell. When you block a receptor it, it should make it more sensitive once you come off.

 

[jinstewart]

Thanks both - yes definitely letting things sit two months now, and some point around then take the "post-cycle bloods" and we'll see what went on.

Fingers still crossed of course. Braced for ups and downs. Will update ofc.

Also hopeful this was useful - go HS experiments crew!

 

[joekool]

Also hopeful this was useful - go HS experiments crew!

Dude this was super helpful! We'll all benefit from this data plus get one step closer to understanding this affliction.

 

[TubZy]

Thanks both - yes definitely letting things sit two months now, and some point around then take the "post-cycle bloods" and we'll see what went on.

Fingers still crossed of course. Braced for ups and downs. Will update ofc.

Also hopeful this was useful - go HS experiments crew!

Yeah, that would be great especially since sleep and a few other things improved. Would be interesting to see if anything changed on the bloods. Although I'm genuinely curious to the DHT value of while you were on RU

 

[Minime]

@jinstewart Read in another thread your rash is completely gone. So happy to hear that you’re not going through the same shit I’m going through. Just had an appointment with my dermatologist today and he has given up. Just can’t understand why my scalp is so inflamed, itchy and Acne. He wants to put me on Accutane. I said no fucking way, LOL. He ended up writing me a script for something to reduce oil production in my skin.

 

[jinstewart]

@jinstewart Read in another thread your rash is completely gone. So happy to hear that you’re not going through the same shit I’m going through. Just had an appointment with my dermatologist today and he has given up. Just can’t understand why my scalp is so inflamed, itchy and Acne. He wants to put me on Accutane. I said no fucking way, LOL. He ended up writing me a script for something to reduce oil production in my skin.

My goodness yes, I read your thread and experience with RU a few times before deciding to roll the dice myself. It sounds like a real trial there, definitely don't envy you. Sending you my best wishes with it, hope it turns around.

My rash was noticeable on the Monday, NOTICEABLE with red face on Tuesday, BAAD on Wednesday, diminished on Thursday, almost gone Friday, barely visible Saturday, totally gone Sunday. Oily skin though returned shortly after the cycle I think, or maybe towards the end. Sleep was AWESOME when cycle finished, then a few flickers this week. I'm DEFINITELY expecting ups and downs though. Mentally, yes also been ups and downs but the trend of (I'd say) psychological improvement and feeling of wellbeing that's set in is truly significant. Like a REAL blow to the jaw for PFS.

DHT results we're STILL waiting for - I'm hoping that'll mean they're so sky high they've been kicking the machine all week, but I'm assured that's tomorrow. Tiny tiny sexual improvements too, return of very weak occasional morning wood also. But occasionally some libido too, just a little fragment.

Lots of 'character' has come back. Gym has been quite good too, although I'm not getting back again until Friday now. This might sound weird too, but I think I 'felt' low estrogen before (clicking aching joints when lifting/living) but especially from today I'd SWEAR estrogen is 'working' again.

This needs running again. I'm going to see how I feel in a month and run another set of 'pre-bloods' again, just to sanity check beforehand. That one will be 7+ days at 1.1g /day. I might also have found a reliable source of mifepristone powder, which (if this pans out) would mean you'd get a whole cycle done for <$180. I'll keep you folks posted.

Thanks everyone. No huge updates but my quality of life has certainly improved, and PFS just took a BIGGG knock! Let's hope this all sticks and we learn a few things.