Fighting….

[bruschi11]

Ray peat “ go to the mountains”…. That’s promoting hif1. Hypoxia promotes hif1.

Also Ray peat “estrogen is really really bad.”

Estrogen (ALA) is required to tolerate hif1. And when converted to estrone by k2 as it should. Raises hif1.

So ray peat totally contradicts himself here.

 

[Yura]

@bruschi11 yeah no hormone or micronutrient is bad. It is all about balance. You could see from some photos of Peat that he was somewhat estrogen dominant.
All that dairy he was consuming without any soluble fiber to clean up the liver..

 

[bruschi11]

@bruschi11 yeah no hormone or micronutrient is bad. It is all about balance. You could see from some photos of Peat that he was somewhat estrogen dominant.
All that dairy he was consuming without any soluble fiber to clean up the liver..

Yea I think you’re right and that’s about my case too. I think soluble fiber is needed here. Been on a dairy kick.

Overnight, literally all the progress I’ve been making on oligoscan with TRT+ nutrients basically died. The two things I added yesterday were 1) k2 (it was strong and chromium raised as I was suspecting) and 2) a long sea water foot bath.

Which is interesting… because long sea water baths were bad in late 2022 when I really needed b12 and methylation to recover.

I didn’t start actually recovering until I started b12 that fall. I also noticed sea water hurting Oligoscans this past summer.

But did the k2 hurt at all? Or was it just the sea water?

I will take k2 every day from here at a normal dose (mk4 500/ mk7 100 mcg) . Stop sea water and switch to epsom salt or sodium sulfate.

Mag dropped in htma. Wonder if it’s sodium chloride presssuring nmda receptor without mag .

 

[bruschi11]

Ok…. Cobalt chloride causes hypoxia in the cell and crazy hif1a issues.

Is the problem chloride? Is it cobalt?

Chromium is pro hif1 as well. Maybe we want to balance chromium with cobalt and chloride?

Maybe we want to stop b12? After yesterday and the oligoscan results… definitely want to stop sea water.

I can tell you for sure hif1 killed ALA and NAD in the last 24 hours.

 

[bruschi11]

I think it’s sulfur before chloride to make nmda receptor work.

Where sulfur feeds taurine. Taurine Beta alanine receive glycine (NAD/ b vitamins). Then glycine puts chloride in the cell.

And that’s ultimately the precursor to electrolytes protocol.

You can’t run electrolytes protocol without high functioning nmda receptor. This is why methylation is so important.

And yes I think if you’re keeping b5 pathways bh4/coa working , beta alanine will inflate. Well BA puts demand on taurine.

I’ve been saying a long time “sulfate feeds taurine”.

So we are gonna see here. No more ocean. Just epsoms/ sodium sulfate.

 

[bruschi11]

Hif1 = akg

VHL= succinate

 

[Fazed22]

Ray peat “ go to the mountains”…. That’s promoting hif1. Hypoxia promotes hif1.

Also Ray peat “estrogen is really really bad.”

Estrogen (ALA) is required to tolerate hif1. And when converted to estrone by k2 as it should. Raises hif1.

So ray peat totally contradicts himself here.

Altitude and Mortality Yeah but the whole point of high altitude is it retains co2 which increases oxygen uptake in the cells so that is anti hypoxia.

 

[bruschi11]

Altitude and Mortality Yeah but the whole point of high altitude is it retains co2 which increases oxygen uptake in the cells so that is anti hypoxia.

This is what I’m trying to say is why estrogen isn’t bad. I’m not saying altitude is bad.

I’m saying estrogen has similar effects as high altitude.

E2 raises ALA the center of pyruvate dehydrogenase which fuels the krebs producing co2.

It’s e1. Which is more hif1/ hydrogen promoter. That can really hurt co2 when in excess.

Which is why we need both ALA and thyroid (coa) working. So we can produce co2 to go with hydrogen.

Hif1 needs both ALA and VHL.

So e1 (hif1) needs both e2(ALA) and thyroid !(VHL) to be down regulated correctly.

So it’s basically estrone needs both T and E2 to be ok.

So a dhea , 4 andro route with low T/e2. Can just be harmful in long run.

And think this may have been my shortfall in late 2022.

Pushed dhea/ 4 andro with low T. Heck I got destroyed this past summer with 4 andro approach.

 

[bruschi11]

very bad crash overnight.

All eyes looking at hcg. Iodine is next thing . But hcg #1. As I’m on it for 2 days now. And what happened overnight into this morning is crazy crazy bad.

It’s all showing on oligoscan. E2 crashed. Boron went really high. Not producing ALA. iodine went up so tyrosine down.

Folate cycle and b6 down.

Complete torture. Coffee enemas helped a little this morning.

VDR = hcg which is tsh mimetic . So I think focusing on VDR (k2/ cr) while taking hcg is horrible.

As tsh then takes tyrosine and iodine for thyroid. Depleting tyrosine killling dopamine and that whole bh4 pathway.

When this happens we see calcium go high in Oligo. As can’t use calcium to create co2.

Sodium raised.

It’s really hard seeing this. As I knew hcg was bad last time I tried trt but not this bad.

It makes sense. Just gotta wait this out and eat good foods .

 

[bruschi11]

It’s crazy how complicated it all seems when it really is that simple.

I think an average TRT dose with decent vitamin / mineral balancing is or was my ticket to decent health. Like it never was that crazy.

T drops and you end up with impaired methylation due to all 3 of T / e2 and e1s affects on minerals, vitamins , amino acids , enzymes .

Fasting lowers T and I did so for 24 days about 2.5 months prior to taking the antibiotic that killed me.

That was a horrible mistake as I needed T for methylation. I needed e2 I needed e1.

 

[bruschi11]

The way coffee enemas helped.

I just think it’s right to just focus on b5 right now. B12 biotin k2 folate choline mag all contribute to b5 when Hormones are in decent place.

 

[bruschi11]

I mentioned this briefly above.

But VDR = production of hcg.

This is what Gbold was looking for.

“””” Research has shown that injecting healthy men with HCG led to an increase in serum levels of calcitriol (the active form of vitamin D). This effect is likely mediated by the luteinizing hormone/HCG receptor (LHCGR), which is expressed in the kidneys, suggesting HCG's influence on calcium and vitamin D metabolism.””””””

Remember the legend of hackstasis…. The one regular who came out on top it seems was JoeKool. Hcg guy.

I’m not saying take hcg. I’m saying fixing VDR helps make hcg. Need to fix VDR as bh4 stays up as ALA stays up.

 

[RebelWithACause]

I mentioned this briefly above.

But VDR = production of hcg.

This is what Gbold was looking for.

“””” Research has shown that injecting healthy men with HCG led to an increase in serum levels of calcitriol (the active form of vitamin D). This effect is likely mediated by the luteinizing hormone/HCG receptor (LHCGR), which is expressed in the kidneys, suggesting HCG's influence on calcium and vitamin D metabolism.””””””

Remember the legend of hackstasis…. The one regular who came out on top it seems was JoeKool. Hcg guy.

I’m not saying take hcg. I’m saying fixing VDR helps make hcg. Need to fix VDR as bh4 stays up as ALA stays up.

Yea JoeKool seemed to really benefit from HCG. I think he inspired me to take it. I felt very good on HCL. Like my brain functioned 100% normal all of a sudden. But this lasted a day. Then after hCG had no good effects at all. Weird stuff

 

[Yura]

@RebelWithACause It is next to impossible balance the body with just micronutrients. Once you start taking hormones as well which are messing with all kinds of feedback loops, receptor sensitivities etc.. You just created so complex problem which can fix maybe some AI 50 years down the road..
Not to mention we know very well from nutritional balancing taking something to "feel good" is not a good strategy in majority of cases..
If I wanted to feel good I would do what everyone else is doing. take all kinds of stimulants, drugs, meds, eat snickers bars and drink monsters. Listening loud music 24/7, watch porn, play PC game all the time etc.. I stopped doing all of that. Feel like shit and for me that feels better ironically. Because now I know how I really feel and if I start to feel better I know it is because my body got actually really healthier not because I just stressed the shit out of my body with some stupid stuff..

 

[RebelWithACause]

@RebelWithACause It is next to impossible balance the body with just micronutrients. Once you start taking hormones as well which are messing with all kinds of feedback loops, receptor sensitivities etc.. You just created so complex problem which can fix maybe some AI 50 years down the road..
Not to mention we know very well from nutritional balancing taking something to "feel good" is not a good strategy in majority of cases..
If I wanted to feel good I would do what everyone else is doing. take all kinds of stimulants, drugs, meds, eat snickers bars and drink monsters. Listening loud music 24/7, watch porn, play PC game all the time etc.. I stopped doing all of that. Feel like shit and for me that feels better ironically. Because now I know how I really feel and if I start to feel better I know it is because my body got actually really healthier not because I just stressed the shit out of my body with some stupid stuff..

Yes of course but HCG is not a drug. Sometimes you feel better just from a better metabolism, bloodflow to brain, hormones to brain. For example once I got out of PFS I felt 1000 times better. Just because hormones worked more normal again and neurotransmitters. That's not bad.

What you say is right tho it's good sometimes to take away excess stressors and rebuild...

 

[Yura]

@RebelWithACause yes it is not a drug. It is a hormone.. I didn't said feeling better is a bad thing. I said taking stuff to feel better is probably not a good idea in most cases. Especially long term and especially if it doesn't address the root cause of why are you taking it in a first place.. So for example taking testosterone if you don't have balls is great. Because there is not better solution. But if you have low testosterone due to bad life style etc.. taking steroids and not addressing the root cause will backfire sooner or later..

 

[bruschi11]

Think I’m gonna really emulate freddd here.

Gonna use GRJ’s methyl/ ado b12 3x daily. I did yesterday with a b complex each time. Said b complex has 1000mg of biotin in each dose.

Feels right.

Chromium cobalt went up in Oligo highest I’ve seen them in awhile. Selenium dropped which we want . Iron copper both mid range.

I think iodine is gonna be needed for this to control hif1.

Obvious ca/mg/zn/ cr.

 

[bruschi11]

did iit again with iodine 125 mcg.

25-50mcg was all I needed last fall and sometimes those would be too much. This was when my testo was higher 350 range from cycling stuff.

Today is insane again.

Seeing P/S/Co raised with dropping i this morning. Calcium being absorbed. D improving all good stuff. But now I really gotta just let this end.

It’s a complete thyroid storm type issue.

I took iodine early 2024 and didn’t think much. I really have to think iodine + hcg were just soooo bad when I tried TRT in early 2024.

I have to be strong here and just let this happen not rush. I can’t work and I just have to accept that. I worked last night and it went well. But here we are again.

 

[Yura]

I am starting to think that iodine really is fucking me up. Even in doses 1-3 drops of lugol where in each drop is 1.39mg of iodine..
I know it does a lot of good things like pathogen, helping metabolize estrogen, detoxing heavy metals, other halogens etc.. But if it is causing a lot of ROS like most people say it does. I think it is doing more harm than good in my case.. Basically always just felt worse from iodine and always was saying to myself it is herx reaction from killing infections and detoxing mercury, bromine, fluoride.. But I am not so sure anymore..

 

[bruschi11]

I am starting to think that iodine really is fucking me up. Even in doses 1-3 drops of lugol where in each drop is 1.39mg of iodine..
I know it does a lot of good things like pathogen, helping metabolize estrogen, detoxing heavy metals, other halogens etc.. But if it is causing a lot of ROS like most people say it does. I think it is doing more harm than good in my case.. Basically always just felt worse from iodine and always was saying to myself it is herx reaction from killing infections and detoxing mercury, bromine, fluoride.. But I am not so sure anymore..

Telling you. Keep it down between 25 and 50 mcg .

And just get potassium iodide.

I have used iodine very effectively at times but low low dose