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also where did you find this post? It's always interesting to hear guys talking about recovering from accutane sex problems either way.

@Willylong98 Dude I would love to believe this could work but I highly doubt it. There is strong reason to believe PAS involves a problem with the central nervous system i.e. the brain. I really can't see how tight muscles or peripheral issues etc. could have such a pronounced, persisting...

Can you remember what dose and for how long you tried it? A guy on the PSSD forums reported that it took around a week of using it to notice a difference. Thinks it cured his PSSD.

Have any PAS people used pramipexole or mirapex before. Did it improve their mental PAS effects such as low libido? I've read peopel reporting improvements after a wekk of 0.5 per day. @Namelk @Willylong98 @tanedout @cnb30 @Lost @CrazyPickles

It's good to share results. Unfortunately, I highly doubt the solution is going to be hormonal. Maybe try out one for Gbol's protocols. Just stay active on the forum. It's good to have as many PAS people as possible

So the results haven't been as significant as we would have hoped. Thanks for trying the FIN and letting us know namelk.

OK so you have had complete remission of sexual symptoms? This indicates that there is no permanent damage but that serotonin signalling is dysfunctional in some way. PSSD and steroids is very interesting. With PAS, steroids have little to no effect. I know accutane can affect dopamine...

@Ghost @Jaxx @Area-1255 Have you met many people with PSSD who have tried altering their hormone levels using steroids etc.? This would be very interesting. Something which has always confused me about PAS, is that steroids had no effect on my sexual sides. If this is also true in PSSD, it...

how long did you take buspirone? It acts on the presynaptic 5HT1A receptor, so I would have thought it would help. When you say SJW gave you a full recovery, what do you mean? Did you sexual side get completely healed temporarily. I only ask this to get an idea of PSSD. It's interesting to...

Most things seem to surpass the androgen receptor. Dopamine agonists don't seem to do much. They act beyond the androgen receptor. I'm very interested in buspirone and maybe even bupropion. If serotonin overactivity is inhibiting dopamine activity. Buspirone may help.

Has anyone tried buspirone???

yeah I still think we need to focus on things which directly affect the brain.

@Ghost I was just wondering man, from your forum which substances have helped reverse PSSD in people? Even if the result couldn't be replicated in everybody else.Are St johns wort? Berberine? or Inositol worth trying?

OK. I still think people need to try RU at higher doses.

Can you remember which PAS sides it helped? did it help sexual sides at all? Interesting that prednisone is a corticosteroid and essentially acts like cortisol. Makes some sense in relation to this study - All-trans retinoic acid-induced hypothalamus–pituitary–adrenal hyperactivity involves...

If you end up taking RU again, it may be worth upping the dose. It's possible 50mg isn't strong enough.

piracetam but I've just read that it may not actually effect acetylcholine.

Did you ever smoke weed before accutane? Was there a difference in the way it affected you? In what way, dont you feel good on weed?

Yes but I think it's more useful to focus on the mental sides as these are the worst to live with and have the biggest impact on peoples quality of life. Trying to work out a theory is useful as it provides new potential treatments to try. I hope you're right and we get there soon.

Thats useful to know. I will be tempted to try St Johns Wort. Again most of these protocols haven't helped people with PSSD. So its still possible that a treatment which works in PSSD, would work for PAS. It would be useful to try a 5HT1A receptor antagonist. Have you ever tried things which...