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I just posted this on acne.org but thought I'd repost here: The only study I could find on accutane and serotonin, found that it increase 5HT1A (serotonin) receptor expression and affected serotonin production and SERT expression - 13-cis-Retinoic acid alters intracellular serotonin, increases...

Ok thanks for letting us know. I still think it's worth other guys giving this a go. I have a few more possible options that I'm working on. Check out my post in the PAS and PSSD thread.

Thanks for such a thorough response. Great to get your opinion on this. Slightly confused with 2) So are you saying that if 5HT1A receptor expression has been excessively increased in the RN due to accutane, then this is likely to be same problem as PSSD? Can you just explain this a little more.

It seems that PAS and PSSD share many of the same symptoms. I've seen on several forums, that many blame the 5HT1A receptor for PSSD. As the auto-receptor version of 5HT1A becomes desensitised due to SSRI use, which persists after stopping the SSRI. As a result there is an excess of 5HT1A...

Ok bro, thanks for letting us know. Do you feel any better or the same?

Can I ask how long you went on accutane for? and was it definitely the cause of your problems?

Hang in there cnb30, where are you from? and are you still studying? It's tough, I've been dealing with this shit for a while now as well. One thing I can say, is depression etc. isn't a definite in this condition. It's possible to beat depression for sure. When you're not depressed, the...

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Thanks for your reply. It's worth considering. But the evidence that FIN reverse accutane's effects is still scant and unreliable. Accutane may also cause hairloss via a process completely unrelated to the process by which FIN prevents. I hope you are right and it is as simple as a mineral...

No news from Namelk. Is there anyone else who is trying Finasteride as a treatment? Or considering it?

I agree, It's good you are taking an active approach. Yes please do a log and update us with your symptoms/story etc. An important question for me, is whether your main side effect is sexual problems or do you also have any other problems such as anhedonia (loss/lack of pleasure)? loss of...

I was just wanting to know if Gbol had made any changes or released any more info regarding post accutane syndrome (PAS) in relation to sexual sides etc. (not hairloss). I appreciate Gbol has written extensively, and is constantly being pestered by people on the forum, so I know he has no...

Yeah as long as you know its real RU. Yeah well I figured its possible that the problem could be progesterone or glucocorticoid insensitivity, which would result in effects being felt after treatment. But on a 50mg dose, I doubt it does much for glucocorticoid sensitivity.

Well done for being the first PAS person to try RU. There was a problem with payment processing on my order, so will need to find alternative means. As I said in other thread, please try to be as honest as possible about results. Even if they are negative and not as we hope. It's good to know...

Can people please state whether their post accutane sexual sides are accompanied by any other significant side effects such as: 1. Depression 2. Anhedonia (get noticeably less pleasure from normally pleasurable activities) 3. Loss of motivation/ drive 4. Loss of interest in socialising, social...

Dasjes, out of interest. Have you noticed any other significant sides with sexual sides such as: 1. Anhedonia (inability to experience pleasure from normally pleasurable things) 2. social isolation / avoidance of social things / social anxiety 3. Depression 4. loss of motivation / drive It's...

Important thing here is to just be completely honest about effects. There is no garuantee RU will help PAS. If it doesn't, its a shame but its best that we know. That way we can look for an alternative or try a different dosage etc.

Any updates from people trying FIN. Any other PAS people considering trying it? Spoke to one of the guys who recovered from it, he's convinced it helped a lot with sexual sides etc.

\how long did you take it and at what dose? Were there any major side effects?

OK and you're sure these effects are related to accutane and not placebo etc.? I only ask because if these side effects are not linked to sexual sides its a positive, if they are, then my worst fear is slightly more confirmed.