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I'm postulating that one possible theory of accutane induced problems is due to accutane increasing D2R expression in regions of the brain such as the striatum. This may persist after treatment and could interfere with normal reward processing in the VTA, due to hyperactivity of the striatum...

mainly sexual sides, maybe some blunted emotions. anxiety is fairly normal. Out of interest Have you suffered any: 1. depersonaization? 2. anhedonia (cannot experience pleasure from things)? 3. Loss of motivation to do things? 4. Less sociable? 5. blunted emotions? are you emotions more...

Hey bro, I've had hair thinning/loss on top of my head but on rest of my body I'm very hairy and so haven't experienced it anywhere else. Do you have any other mental sides apart from sexual sides?

No idea how long it will take for pill to arrive. It's just useful to know or see if PAS people with sexual sides have high or low prog or if there is no correlation.

you will have to get from the source tubzy recommended. Its not cheap but its depends how much you value trying to figure out a way to fix this.

Hard to say which side effects are due to accutane or a result of other side effects. Only side effect I really care about right now, is sexual sides. I will be monitoring these when taking RU. Do you have sexual sides? Also have you ever had your progesterone tested?

So you're progesterone was 0.9 ng/ml??? This is very very high and could definitely explain changes in sex drive/ libido. The thing is, have you ever had this tested before accutane? Perene, you seem to be good at researching and looking into stuff. I have looked myself and struggled to find...

Does anyone have any links to any papers showing that accutane or a metabolite of accutane such as atra increases progesterone? I have found one paper in rats but I can't find anything else. And can anyone provide evidence or a theory of how accutane could increase progesterone? Thanks

I've ordered one 200mg pill to see if the website is trustworthy. I will split the pill up and weigh it into 50mg doses. I will take 50mg for 4 days and see how I feel afterwards. This is based on the logs of PFS people who have tried RU. Depending how this cycle goes, I will consider doing a...

OK, does anyone have a link to the paper which talks about finasteride being a progestin or derived from progesterone? If Fin truly is a progestin (I'm only questioning this as I've not seen or read about this anywhere other than this forum), then Gbol's work to link Fin to things like deca dick...

Could anybody confirm something for me. Given this new zinc finger approach to PFS, is Gbol discounting his progestin theory of finasteride? Or is this just an additional idea of how PFS could arise/ be treated. Could they both be correct simultaneously? I'm just confused as there was much talk...

I remember shedding whilst on accutane quite a lot of hair. However I don't seem to be shedding anywhere near the same level now. I also don't know if my shed shed now is just normal level of hair shedding. My opinion on this, I could be completely wrong, is that accutane does induce shedding...

Yes I actually doubt RU will help directly in relation to hormones, I think this will help in regards to changing receptor activity/expression. I could be wrong, but there is far too much evidence now to not give this a try. It's crazy that pretty much nobody with PAS has tried this yet...

I will get progesterone, cortisol and estrogen tested before trying RU. However even if my results come back normal, I still intend to try this medication. As normal hormone levels don't say much in regards to receptor expression of activity.

Right now R-andro doesn't seem like it would do much as people who have experimented with high levels of steroids have seen little if any positive results. Ella is a weaker form of RU and doesn't effect cortisol. RU has an effect on both cortisol and prog, and it has been shown to have...

Right now, nobody really knows whats going on. The symptoms of PFS and PAS etc. are similar but there is no reason to assume they are caused the by the same problem. I am currently doing some research to try to provide a hypothesis or possible theory. As you say, its very difficult as most...

Ok, many males on this forum have tried it. RU is not the kind of drug that will leave you with any long term side effects. I intend to take it soon. So I will let you know how it goes for me first, then you can decide.

If you give RU a try, could you do a log please. It will very informative to get logs of PAS people who try RU

Did you say you tested high for progesterone after accutane? Have you had any more tests for progesterone?

do you know how long after accutane this was? Its very interesting that your progesterone is at the top of the range, this could be a great thing to target. Is it possible progesterone is this high becaue you were on TRT? Do you have sexual sides?