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Same question to you bro, did you notice any big difference in the effect of weed before and after accutane? Or was it pretty much the same?

Out of interest. Did you notice any difference in the effect smoking weed had before and after accutane? Like did it effect you differently? Enjoy it less? Or was it pretty much the same?

For any PAS sufferers out there, I couldn't copy the text but on page 180. It links accutane usage to both folate deficiency and elevated homocysteine levels, which I remember Gbol mentioning. Nobody had mentioned this specifically before, but high homocysteine levels can lead to decreased DNA...

hi brix, are you PFS or post accutane?

Hang in there bro. Remember you had a good temporary recovery after accutane, this shows you're problems aren't caused by permanent damage. Thats a big positive. I don't understand the whole prog receptors thing fully yet or how it fits in with accutane. I think you're best off asking Gbol.

Yes well thats one positive thing at least, it shows there probably isn't any physical damage to the penis which could arguably be harder to treat. So you started having low libido whilst on accutane, can you remember how many weeks on accutane before libido started to decline. Then...

Its useful to know that the sexual side effects didn't start once you stopped the accutane but started during treatment. This shows that the effects aren't the result of a withdrawal of retinoic acid. To be honest, I think the physical sides like erections etc. are related to the libido issue...

Hi guys, I'm not sharing this to promote another website etc. for personal gain, I've donated myself. I simply think the success and support of a project like this, will help us all. This is one of the only organisation which is taking these conditions seriously. If people suffering from these...

Did the other non-sexual side effects start after stopping accutane or during the treatment? I'm in a similar position, my problem is that I took tane when I was just 14 years so I wasn't as aware of the changes when they happened, didn't take note of specific changes etc. always assumed things...

Right, but does elevated cortisol lead to elevated progesterone? I understand that progesterone can lead to sexual problems. I'm just still struggling to make the link between zinc-finger and progesterone in a significant way. From a quick look online, cortsiol seems to oppose progesterone...

Just out of interest did you loss of libido start whilst on accutane or after stopping? Was there a significant difference between before accutane and after in terms of libido/arousal? Also do you have any other side effects such as social withdrawal? anxiety? depression? emotional blunting...

Hi there, Is anyone able to give a brief overview of how cortisol insensitivity caused by a lack of/desensitized zinc finger (glucocorticoid receptor) could cause the sexual side effects of PFS? I sort of understand the theory and find it really interesting as there are reasons to believe that...

If you copy what he took, please keep me posted on how you feel. I would be very interested in whether we could replicate the reversal of symptoms in another PAS sufferer. Pretty sure he took a variety of stuff, but trestolone (MENT) had greatest effect. If you do take this regime, I'd also...

ah OK, have you ever had a blood tests for cortisol? Or just saliva?

What makes you think you have adrenal insufficiency? Didn't you say you tested high for DHEA-S, thats an adrenal steroid which would indicate adrenal hyperactivity. All-trans retinoic acid-induced hypothalamus–pituitary–adrenal hyperactivity involves glucocorticoid receptor dysregulation...

I couldn't access this article, only the abstract. I'm not sure what the relevance of this is? I think the article is simply saying that the results for test and estradiol blood tests can be affected if you are taking RU. This article is interesting, I didn't know that RU was an androgen...

Could people try to post their symptoms with their blood results as it avoids confusion. For instance, PAS sufferer 1 may have skin problems whilst PAS sufferer 2 has libido issues. If they both post bloods with conflicting results without stating symptoms. We may deduce that one hormone can't...

Would be useful to know DHEA-S, cortisol and progesterone. Depending where you are based, you can go private. In the UK, I got my DHEA-S tested along with test and some others as part of a package was fairly cheap and easy. To be honest, having test of 540-571 ng/dl whilst not super high, isn't...

Have you ever had DHEA-S tested? I think knowing peoples DHEA-S and cortisol could prove useful.

I will start with myself. Main symptoms loss of libido, depression and some anhedonia, anxiety but this may be indirectly related to accutane. Note DHEA-S is only abnormal result. I plan to get progesterone, cortisol and estrogen done. Note that the problem is not likely related to IGF-1/growth...